Transkaryotic Therapies, Inc.
Ticker: TKTX 195 Allbany Street
Exchange: NASDAQ-National Market Cambridge, Massachusetts 02139
Industry: Manufacturing (617) 349-0200

Type of Shares:Common Shares Filing Date:8/27/96
U.S. Shares:2,500,000 Offer Date:10/16/96
Non-U.S. Shares:0 Filing Range:$13.00 - $15.00
Primary Shares:2,500,000 Offer Price:$15.00
Secondary Shares:0 Gross Spread:$1.05
Offering Amount: $35,000,000 Selling:$0.63
Expenses:$790,000 Reallowance:$0.10
Shares Out After:16,616,415

ManagerTierPhone
Morgan Stanley & Co. IncorporatedLead Manager (212) 703-4797
Pacific Crest Securities Inc.Co-manager (503) 248-0721
UBS Securities Inc.Co-manager (212) 230-4000

Auditor: Ernst & Young
Audited
Income
Latest
Unaudited
Income
Prior
Unaudited
Income
Balance
Sheet
12/31/95 6/30/96 6/30/95 6/30/96
Revenue:$15.40$1.98$11.70Assets:$33.63
Net Income:$2.07-$5.99$5.11Liabilities:$5.74
EPS:$0.14-$0.42$0.35Equity:$27.89

Note: Dollar amounts are in U.S. millions; Audited figures expressed as full year,
unaudited figures are partial year

Business Description
The company has developed two proprietary technology platforms, Gene Activation and gene therapy. The company's Gene's Activation technology is a proprietary approach to the large scale production of therapeutic proteins which does not require the cloning of genes and their subsequent insertion into non-human cell lines. Consequently, the company believes its Gene Activation technology avoids using patented approaches to protein production associated with such conventional genetic engineering which have served as effective barriers to competition in the $11 billion therapeutic protein market. As a result, the company believes it will be able to develop and successfully commercialize a broad range of gene activated approval from regulatory authorities and generated significant revenues in major markets.

Use of Proceeds
The proceeds from the proposed offering will be used for research, preclinical and clinical product development, and general corporate purposes.

Last updated: 11/3/96

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