Trimeris, Inc.
Ticker:TRMS 4727 University Drive, Suite 100
Exchange:NASDAQ-National Market Durham, NC 27707
Industry:Service (SIC Code 8733) (919) 419-6050

Offering Information
Type of Shares:Common Shares Filing Date:7/11/97
U.S. Shares:2,750,000 Offer Date:10/6/97
Non-U.S. Shares:0 Filing Range:$12.00 - $14.00
Primary Shares:2,750,000 Offer Price:$12.00
Secondary Shares:0 Gross Spread:$0.84
Offering Amount: $35,750,000 Selling:$0.49
Expenses:$800,000 Reallowance:$0.10
Shares Out After:9,864,676

Primary Underwriting Group
ManagerTierPhone
UBS Securities Inc.Lead Manager (212) 821-4510
Montgomery SecuritiesCo-manager (415) 627-2100

Legal Counsel, Auditor and Registrar
Issuer's Law Firm: Wilmer, Cutler & Pickering
Bank's Law Firm: Brobeck, Phleger & Harrison
Auditor: KPMG Peat Marwick
Registrar/Transfer Agent: Wachovia Bank of North Carolina

Selected Financial Data

Dollar amounts in U.S. millions except for per share data
6 Month Ending Financials
Full Year
Audited
Income
Latest
Unaudited
Income
Prior
Unaudited
Income
Balance
Sheet
12/31/96 6/30/97 6/30/96 6/30/97
Revenue:$0.06$0.21$0.00Assets:$10.59
Net Income:-$6.97-$3.48-$3.13Curr Assets:
EPS:-$1.48-$0.59Liabilities:$1.74
Prior EPS:-$3.50-$2.88Curr Liabilities:
Cash Flow/Oper:-$15.06Equity:$8.85
Cash Flow/Fin:Cash:
Cash Flow/Inv:

Business Description
The company is a biopharmaceutical company engaged in the discovery and development of novel therapeutic agents that block viral infection by inhibiting viral fusion with host cells. The company's lead product candidate, T-20, inhibits fusion of the Human Immunodeficiency Virus-1 (HIV) with host cells. T-20 is currently being tested in a Phase I/II clinical trial in HIV-infected patients in the United States. T-20 and the company's other product candidates are designed to inhibit viral fusion, unlike other currently approved therapeutic agents that target replicating viruses inside infected cells. The company has developed a proprietary technology platform in the field of fusion inhibition which is being applied to the discovery and development of novel products for the treatment of a variety of viarl diseases.

Competition
The company is engaged in segments of the biopharmaceutical industry including the treatment of HIV, that are intensely competitive and rapidly changing. If successfully developed and approved, the product candidates and compounds that the company is currently developing will compete with numerous existing therapies. For example, 11 drugs are currently approved for the treatment of HIV. In addition, a number of companies are pursuing the development of novel pharmaceutical products that target the same diseases that the company is targeting, and some companies, including several multinational pharmaceutical companies, are simultaneously marketing several different drugs and may therefore be able to markettheir own combination drug therapies. The company believes that a significant number of drugs are currently under development and will become available in the future for the treatment of HIV. Although the company believes that there is a significant future market for therapeutics that treat HIV and other viral diseases, the company anticipates that it will face intesne and increasing competition in the future as new products enter the market and advanced technologies become available. There can be no assurance that exiting products or new products for the treatment of HIV developed by the company's competitors, including Glaxo, Merck and Abbott, will not be more effective or more effectively marketed and sold, than T-20, should it be successfully developed and receive regulatory approval, or any other therapeutic for HIV that may be developed by the company.

Business Plan
The company's goal is to become a leader in anti-fusion viral therapy. To achieve this objective, the principal elements of the company's strategy are to: (I) Validate Fusion Inhibition Therapy By Obtaining Regulatory, (ii) Leverage Anti-Fusion Expertise To Develop Other Antiviral Therapies and (iii) Tailor Commercialization Capabilities To Specific Product Markets.

Use of Proceeds
The proceeds from the proposed offering will be used to fund increased research and development activities, to fund expansion of facilities, to provide working capital and to fund other general corporate purposes.

Principal and Selling Shareholders
Name of Shareholder% Owned
Before
% Owned
After
Jesse I. Treu35.00%26.10%
DP III Associates, L.P.35.00%26.10%
Domain Partners III, L.P.35.00%26.10%
Domain Partners II, L.P.35.00%26.10%
Biotechnology Investments Limited17.60%13.10%
Sentron Medical, Inc.5.30%4.00%
Note: Represents ownership of 5% or more prior to the offering.
Executive Officers and Directors
Officer NameTitleAge
Jesse I. Treu, Ph.D.Chairman of the Board of Directors50
Matthew A. MegaroChief Operating Officer, Chief Financial Officer, Executive Vice President and Secretary39
Michael A. Recny, Ph.D.Director of Business Development41
M.C. Kang, Ph.D.Director of Chemisty45
Timothy J. CreechDirector of Finance36
M. Ross Johnson, Ph.D.President, Chief Executive Officer, Chief Scientific Officer and Director52
Dennis M. Lambert, Ph.D.Vice President of Biological and Molecular Sciences50
Samuel Hopkins, Ph.D.Vice President of Medical Affairs38

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