IPO Company Profile
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CombiChem, Inc.
9050 Camino Sante Fe, San Diego, CA 92121 * (619) 530-0484

The company is a computational drug discovery company that is applying its proprietary design technology and rapid synthesis capabilities to accelerate the discovery process for new drugs.

Primary Underwriting Group
ManagerTierPhone
BancAmerica Robertson StephensLead Manager (415) 989-8500
Donaldson, Lufkin & Jenrette Securities Corp.Co-manager (212) 371-0641
Salomon Smith BarneyCo-manager (212) 723-7300

Offering Information
NASNTL:CCHM Service: SIC 8731
Type of Shares:Common Shares Filing Date:10/15/97
U.S. Shares:2,250,000 Offer Date:5/7/98
Non-U.S. Shares:0 Filing Range:$8.00 - $10.00
Primary Shares:2,250,000 Offer Price:$8.00
Secondary Shares:0 Gross Spread:$0.56
Offering Amount: $20,250,000 Selling:$0.32
Expenses:$700,000 Reallowance:$0.10
Post-IPO Shares:13,168,505
Employees:56

Legal Counsel, Auditor and Registrar
Issuer's Law Firm: Brobeck, Phleger & Harrison
Bank's Law Firm: Cooley Godward Castro Huddleson & Tatum
Registrar/Transfer Agent: American Stock Transfer & Trust Co
Auditor: Ernst & Young

Selected Financial Data

Dollar amounts in U.S. millions except for per share data
9 Month Ending Financials
Full Year
Audited
Income
Latest
Unaudited
Income
Prior
Audited
Income
Balance
Sheet
12/31/96 9/30/97 9/30/96 9/30/97
Revenue:$2.97$4.60$1.07Assets:$13.36
Net Income:-$5.12-$3.67-$4.46Curr Assets:$8.92
EPS:-$0.66-$0.45Liabilities:$29.22
Prior EPS:Curr Liab:$3.63
Cash Flow/Oper:-$2.37-$3.73-$4.40Equity:-$15.85
Cash Flow/Fin:$12.18-$0.16$2.55Cash:$8.40
Cash Flow/Inv:-$12.57$7.81-$0.31Working Cap:$5.29

Competition
Many organizations are actively attempting to identify, optimize and generate lead compounds for potential pharmaceutical development. The Company competes with the research departments of pharmaceutical companies, biotechnology companies, combinatorial chemistry companies and research and academic institutions as well as other computationally based drug discovery companies. Many of these competitors have greater financial and human resources and more experience in research and development than the Company. Historically, large pharmaceutical companies have maintained close control over their research activities, including the synthesis, screening and optimization of chemical compounds. Many of these companies, which represent one of the largest potential markets for CombiChem's products and services, are internally developing combinatorial and computational approaches and other methodologies to improve productivity, including major investments in robotics technology to permit the automated parallel synthesis of compounds. In addition, these companies may already have large collections of compounds previously synthesized or ordered from chemical supply catalogs or other sources against which they may screen new targets. Other sources of compounds include compounds extracted from natural products, such as plants and microorganisms, and compounds created using rational drug design. Academic institutions, governmental agencies and other research organizations are also conducting research in areas in which the Company is working, either on their own or through collaborative efforts. The Company anticipates that it will face increased competition in the future as new companies enter the market and advanced technologies become available. The Company's processes may be rendered obsolete or uneconomical by technological advances or entirely different approaches developed by one or more of the Company's competitors. The existing approaches of the Company's competitors or new approaches or technology developed by the Company's competitors may be more effective than those developed by the Company.

Business Plan
The Company's objective is to be the industry leader in the generation, evolution and optimization of novel lead candidates. The Company intends to utilize its scientific and technology assets in the discovery process through a mix of collaborative and internal programs by applying the following business strategies: (I) To establish multiple collaborations with large pharmaceutical and biotechnology companies focused on biological targets chosen by the collaborators, (ii) To partner with companies to apply discovery technologies to jointly agreed-upon biological targets, (iii) To conduct internal discovery efforts aimed at selected biological targets, retaining a larger economic interest in the subsequently outlicensed lead candidates, (iv) To expand collaborative opportunities in alternative industries such as the agrochemical field and (v) To maintain technology leadership in both software development and rapid synthesis capbilities.

Use of Proceeds
The proceeds from the proposed offering will be used to fund research and development, expansion of laboratory and office facilities, working capital and for general corporate purposes.

Principal and Selling Shareholders
Name of Shareholder% Owned
Before
% Owned
After
Sprout Capital VII, L.P. and affiliated entities0.140.11
Philippe O. Chambon, MD., Ph.D.0.140.11
Sequoia Captial VI and affiliated entities0.110.09
Pierre R. Lamond0.110.09
Elan International Services Ltd.0.090.08
Brinson MAP Venture Capital Fund III and affiliated entities0.090.07
Sorrento Growth Partners I, L.P. and affiliated entities0.070.06
Vicente Anido, Jr., Ph.D.0.050.04
Note: Represents ownership of 5% or more prior to the offering.
Executive Officers and Directors
Officer NameTitleAge
Pierre R. LamondChairman of the Board and Director67
Vicente Anido, Jr., Ph.D.President, Chief Executive Officer and Director44
Steven L. TeigVice President, Advanced Technology36
Peter L. Myers, Ph.D.Vice President, Chief Scientific Officer, Chief Operating Officer and Director53
Karin EasthamVice President, Finance and Administration and Chief Financial Officer47
John Saunders, Ph.D.Vice President, Medicinal Chemistry49
Klaus Gubernator, Ph.D.Vice President, Special Projects44
Lee R. McCrackenVicel President, Business Development39

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